Waifish Irina (Natassja Kinski) meets her older brother, Paul (Malcolm McDowell), a minister, for the first time since their animal trainer parents died and she was sent to a series of foster homes. Paul's Creole housekeeper, Female (Ruby Dee), helps Irina settle into her brother's home, but Paul himself disappears. Cut to a fleabag motel where a blas prostitute finds an angry panther instead of a client; after mauling her, the cat is captured by police and a team of zoologists: Oliver (John Heard), Alice (Annette O'Toole), and Joe (Ed Begley Jr.). The next day Irina finds herself in the zoo where these scientists work; drawn to the newly captured panther, she befriends Oliver and takes a job in the gift shop. Shortly after the panther's violence turns deadly, it escapes, and soon Paul turns up spouting an unbelievable story about his family's were-cat heritage and his inevitable sexual union with little Irina.